NMR Hall Gif-sur-Yvette
Platform name
Institute of Chemistry of Natural Products - High Field NMR Platform
Villas
Gif-sur-yvette
Find Us Here

1 avenue of the terrace, 91190, Gif-sur-Yvette

Scientific Officer
Dr. Ewen Lescop (This e-mail address is protected against spambots. You need JavaScript enabled to view it.)
Operational manager
Dr. Nelly Morellet (This e-mail address is protected against spambots. You need JavaScript enabled to view it.)
Communication correspondent
Mr. Francois Giraud (This e-mail address is protected against spambots. You need JavaScript enabled to view it.)
Management manager
Ms. Alda Da Costa (This e-mail address is protected against spambots. You need JavaScript enabled to view it., Phone: 01 69 82 36 71)

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The Gif-sur-Yvette Infranalytics platform includes:


NMR Gif High pressure 637a1NMR Gif IMG 1779 072df• A 950 MHz Bruker Avance III-HD spectrometer equipped with a TCI cryoprobe (1H,13C,15N,2H) 5mm, z-gradients (S/B = 9307) working from 0°C to 80°C, compatible with oval tubes (saline samples)

• “Deadalus inc” equipment for carrying out high-pressure NMR experiments, with 1 ceramic tube (1 bar to 3 kbar)

NMR experiments available:
Fast NMR (BEST, SOFAST, ...), Nonlinear sampling or projection methods, 3D, 4D triple resonance experiment for proteins and nucleic acids, Relaxation and Relaxation Dispersion, Residual Dipole Couplings, Methyl NMR, Protein Interactions ligands, DOSY, paramagnetic NMR (PRE/PCS).

Main areas of application:
Structure, dynamics and interactions of biological macromolecules; small molecules in small quantities (natural products).

 
 
 
Resp. This e-mail address is protected against spambots. You need JavaScript enabled to view it. (33-(0)169823764); Corr. This e-mail address is protected against spambots. You need JavaScript enabled to view it. (33-(0)169823762); Secr-management This e-mail address is protected against spambots. You need JavaScript enabled to view it. (33-(0)169823671)

Fully

BRUKER Avance III HD 950

Description
Ultrastabilized and ultrashielded Narrow Bore Magnet 950/54 @ 22.31T. Avance III HD generation console of electronics (4 channels). TopSpin 3.6 user interface.
Specifics
High pressure apparatus (1-3000 bar)
Measurement probes

Triple resonance liquid state z-gradient ATMA probes:

  • TCI cryoprobe
  • TXI classical probe
Expertise and services
  • Design of structural study projects by NMR adapted to the systems and questions asked and support for the teams at each stage: allocation of resonances, study of dynamics, determination of 3D structures, interactions, titrations, kinetics, etc.
  • Performing multi-nucleus NMR experiments (1H, 2H, 13C, 15N, 19F, 31P), fast NMR (BEST, SOFAST, ...), paramagnetic and high pressure NMR
  • Use of nonlinear sampling methods or projections
  • Performing 3D and 4D triple resonance experiments for proteins and nucleic acids
  • Performing Relaxation, Relaxation Dispersion, Residual Dipole Coupling and Diffusion (DOSY) Experiments
  • Recording of methyl-specific NMR spectra
  • Recording of NMR experiments for the characterization of protein-ligand interactions
  • Data analysis and interpretation with user training
  • Provision of spectrometers with support for experienced users.
Other equipment

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The 950MHz spectrometer is integrated into the platform RMNHC@UPSAY, NMR node of the FRISBI infrastructure (French Research Integrated Structural Biology Infrastructure), labeled IBISA, of which 5 of the 6 spectrometers are currently managed by the "RMN, Biologie et Chimie Structurales" team of the Institute of Chemistry of Natural Substances, on the CNRS campus of Gif-sur-Yvette. Research on campus is essentially centered on chemistry and biology, with a strong structural biology component in a biology and health context. The Gif campus is part of the "grand campus Paris-Saclay" (https://www.universite-paris-saclay.fr/), which brings together more than 10000 researchers from all scientific backgrounds, and a strong community of researchers in structural biology (Gif-sur-Yvette, University of Paris 11, the CEA in Saclay and the SOLEIL synchrotron).

800 MHz Bruker Avance III Liquid

Liquid probe:
Cryo TCI (1H, 13C, 15N, 2H), 5mm, z-gradients

700 MHz Bruker Avance NEO Liquid

TXO liquid probe (1H, 13C, 15N, 2H), 5mm, z-gradients

600 MHz (Bruker-1) Bruker Avance III Liquid

Liquid probes:

  • Cryo TCI (1H, 13C, 15N, 2H), 5mm, z-gradients
  • Cryo QCI (1H, 13C, 15N, 19F, 2H), 5mm, z-gradients
  • SampleJet autosampler (with temperature control)

600 MHz (Bruker-2) Bruker Avance III Liquid

Liquid probes:

  • TXI (1H, 13C, 15N, 2H), 5mm, x,y,z-gradients
  • TBI (1H, 13C BB), 5mm, x,y,z-gradients

In addition, an NMR service is available to chemists, with one 600MHz, two 500MHz and two 300MHz.

Some recent publications

Exploration of the dynamic interplay between lipids and membrane proteins by hydrostatic pressure.

Pozza A. Giraud F, Cece Q, Casiraghi M, Point E, Damian M, Le Bon C, Moncoq K, Banères JL, Lescop E, Catoire L J. Nat Commun. 2022 Apr 1;13(1):1780. doi: 10.1038/s41467-022-29410-5. Online ahead of print. PM ID: 35365643

Optimization of spatially-encoded diffusion-ordered NMR spectroscopy for the analysis of mixtures.

Jacquemmoz C, Mishra R, Guduff L, van Heijenoort C, Dumez JN. Magn Reson Chem. 2022 Jan;60(1):121-138. doi: 10.1002/mrc.5194. Epub 2021 Sep 2. PMID: 34269476

Nuclear Magnetic Resonance Spectroscopy: A Multifaceted Toolbox to Probe Structure, Dynamics, Interactions, and Real-Time in Situ Release Kinetics in Peptide-Liposome Formulations.  

Dean C, Larquet E, Coureux PD, Frances O, Herman F, Sablé S, Burnouf JP, Sizun C, Lescop E. MolPharm. 2021 Jul 5;18(7):2521-2539. doi: 10.1021/acs.molpharmaceut.1c00037. Epub 2021 Jun 20. PMID: 34151567

Revisiting the Molecular Interactions between the Tumor Protein TCTP and the Drugs Sertraline/Thioridazine.  

Malard F, Backgammon E, Nhiri N, Sizun C, Chabrier A, Messaoudi S, Dejeu J, Betzi S, Zhang X, Thureau A, Lescop E. ChemMedChem. 2022 Jan 5;17(1):e202100528. doi: 10.1002/cmdc.202100528. Epub 2021 Oct 6. PMID: 344727

Investigation of the Low-Populated Excited States of the HIV-1 Nucleocapsid Domain.

Mouhand A, Zargarian L, Belfetmi A, Catala M, Pasi M, Lescop E, Tisné C, Mauffret O. Viruses. 2022 Mar 18;14(3):632. doi: 10.3390/v14030632. PM ID: 35337039

Interactions between the Nucleoprotein and the Phosphoprotein of Pneumoviruses: Structural Insight for Rational Design of Antivirals.  

Decool H, Gonnin L, Gutsche I, Sizun C, Eléouët JF, Galloux M. Viruses. 2021 Dec 6;13(12):2449. doi: 10.3390/v13122449. PMID: 34960719

Expanding the Disorder-Function Paradigm in the C-Terminal Tails of Erbbs.  

Pinet L, Assir N, van Heijenoort C. Biomolecules. 2021 Nov 14;11(11):1690. doi: 10.3390/biom11111690. PM ID: 34827688

Relationships between RNA topology and nucleocapsid structure in a model icosahedral virus.

Marichal L, Gargowitsch L, Rubim RL, Sizun C, Kra K, Bressanelli S, Dong Y, Panahandeh S, Zandi R, Tresset G. Biophys J. 2021 Sep 21;120(18):3925-3936. doi: 10.1016/j.bpj.2021.08.021. Epub 2021 Aug 19. PMID: 34418368

β-Hairpin Peptide Mimics Decrease Human Islet Amyloid Polypeptide (hIAPP) Aggregation.

Lesma J, Bizet F, Berardet C, Tonali N, Pellegrino S, Taverna M, Khemtemourian L, Soulier JL, van Heijenoort C, Halgand F, Ha-Duong T, Kaffy J, Ongeri S. Front Cell Dev Biol. 2021 Sep 16;9:729001. doi: 10.3389/fcell.2021.729001. eCollection 2021. PMID: 34604227

A Structural and Dynamic Analysis of the Partially Disordered Polymerase-Binding Domain in RSV Phosphoprotein.  

Cardone C, Case CM, Bardiaux B, Thureaux A, Galloux M, Bajorek M, Eléouët JF, Litaudon M, Bontems F, Sizun C. Biomolecules. 2021 Aug 17;11(8):1225. doi: 10.3390/biom11081225. PM ID: 34439894

The unusual structure of the PiggyMac cysteine-rich domain reveals zinc finger diversity in PiggyBac-related transposases.

Guerineau M, Bessa L, Moriau S, Lescop E, Bontems F, Mathy N, Guittet E, Bischerour J, Bétermier M, Morellet N. MobDNA. 2021 Apr 29;12(1):12. doi: 10.1186/s13100-021-00240-4. PMID: 33926516

Structural and dynamic characterization of the C-terminal tail of ErbB2: Disordered but not random.

Pinet L, Wang YH, Deville C, Lescop E, Guerlesquin F, Badache A, Bontems F, Morellet N, Durand D, Assrir N, van Heijenoort C. Biophys J. 2021 Mar 17:S0006-3495(21)00234-4. doi: 10.1016/j.bpj.2021.03.005. Online ahead of print. PMID: 33741354

Drimane Derivatives as the First Examples of Covalent BH3 Mimetics that Target MCL-1.

Daressy F, Malard F, Seguy L, Guérineau V, Apel C, Dumontet V, Robert A, Groo AC, Litaudon M, Bignon J, Desrat S, Malzert-Fréon A, Wiels J, Lescop E, Roussi F. ChemMedChem. 2021 Mar 5. doi: 10.1002/cmdc.202100011. Online ahead of print. PMID: 33665938

Pneumoviral Phosphoprotein, a Multidomain Adaptor-Like Protein of Apparent Low Structural Complexity and High Conformational Versatility.

Cardone C, Caseau CM, Pereira N, Sizun C. Int J Mol Sci. 2021 Feb 3;22(4):1537. doi: 10.3390/ijms22041537. PMID: 33546457 Free PMC article. Review.

Fluorinated Triazole Foldamers: Folded or Extended Conformational Preferences.

Laxio Arenas J, Xu Y, Milcent T, Van Heijenoort C, Giraud F, Ha-Duong T, Crousse B, Ongeri S. Chempluschem. 2021 Feb;86(2):241-251. doi: 10.1002/cplu.202000791. PM ID: 33555641

Tetramerization of Phosphoprotein is Essential for Respiratory Syncytial Virus Budding while its N Terminal Region Mediates Direct Interactions with the Matrix Protein.

Bajorek M, Galloux M, Richard CA, Szekely O, Rosenzweig R, Sizun C, Eleouet JF. J Virol. 2021 Jan 6:JVI.02217-20. doi: 10.1128/JVI.02217-20. Online ahead of print. PM ID: 33408180

Nonsymmetrical Dynamics of the HBV Capsid Assembly and Disassembly Evidenced by Their Transient Species.

Chevreuil M, Lecoq L, Wang S, Gargowitsch L, Nhiri N, Backgammon E, Zinn T, Fieulaine S, Bressanelli S, Tresset G. J Phys Chem B. 2020 Nov 12;124(45):9987-9995. doi: 10.1021/acs.jpcb.0c05024. Epub 2020 Nov 2. PMID: 33135897

A seven-residue deletion in PrP leads to generation of a spontaneous prion formed from C-terminal C1 fragment of PrP.

Munoz-Montesino C, Larkem D, Barbereau C, Igel-Egalon A, Truchet S, Backgammon E, Nhiri N, Moudjou M, Sizun C, Rezaei H, Béringue V, Dron M. J Biol Chem. 2020 Oct 9;295(41):14025-14039. doi: 10.1074/jbc.RA120.014738. Epub 2020 Aug 11. PMID: 32788216 Free article.

Cyclodextrin complexation studies as the first step for repurposing of chlorpromazine.

Wang Z, Landy D, Sizun C, Cézard C, Solgadi A, Przybylski C, de Chaisemartin L, Herfindal L, Barratt G, Legrand FX. Int J Pharm. 2020 Jun 30;584:119391. doi: 10.1016/j.ijpharm.2020.119391. Epub 2020 May 4. PMID: 32376444

NMR Characterization of the Influence of Zinc(II) Ions on the Structural and Dynamic Behavior of the New Delhi Metallo-β-Lactamase-1 and on the Binding with Flavonols as Inhibitors.

River G, Oueslati S, Gayral M, Créchet JB, Nhiri N, Backgammon E, Cintrat JC, Giraud F, van Heijenoort C, Lescop E, Pethe S, Iorga BI, Naas T, Guittet E, Morellet N. ACS Omega. 2020 Apr 28;5(18):10466-10480. doi: 10.1021/acsomega.0c00590. eCollection 2020 May 12. PMID: 32426604 Free PMC article.

Ubiquitin is double-phosphorylated by PINK1 for enhanced pH-sensitivity of conformational switch.

Ye SX, Gong Z, Yang J, An YX, Liu Z, Zhao Q, Lescop E, Dong X, Tang C. Protein Cell. 2019 Dec;10(12):908-913. doi: 10.1007/s13238-019-0644-x. PMID: 31278634 Free PMC article. No abstract available.

Defects in t6A tRNA modification due to GON7 and YRDC mutations lead to Galloway-Mowat syndrome.

Arrondel C, Missoury S, Snoek R, Patat J, Menara G, Collinet B, Liger D, Durand D, Gribouval O, Boyer O, Buscara L, Martin G, Machuca E, Nevo F, Lescop E, Braun DA, Boschat AC, Sanquer S, Guerrera IC, Revy P, Parisot M, Masson C, Boddaert N, Charbit M, Decramer S, Novo R, Macher MA, Ranchin B, Bacchetta J, Laurent A, Collardeau-Frachon S , van Eerde AM, Hildebrandt F, Magen D, Antignac C, van Tilbeurgh H, Mollet G. Nat Commun. 2019 Sep 3;10(1):3967. doi: 10.1038/s41467-019-11951-x. PMID: 31481669 Free PMC article.

Physiologically relevant reconstitution of iron-sulfur cluster biosynthesis uncovers persulfide-processing functions of ferredoxin-2 and frataxin.

Gervason S, Larkem D, Mansour AB, Botzanowski T, Müller CS, Pecqueur L, Le Pavec G, Delaunay-Moisan A, Brun O, Agramunt J, Grandas A, Fontecave M, Schünemann V, Cianférani S, Sizun C, Tolédano MB, D'Autréaux B. Nat Commun. 2019 Aug 8;10(1):3566. doi: 10.1038/s41467-019-11470-9. PMID: 31395877 Free PMC article.

Natural Chlordecone Degradation Revealed by Numerous Transformation Products Characterized in Key French West Indies Environmental Compartments.

Chevallier ML, Della-Negra O, Chaussonnerie S, Barbance A, Muselet D, Lagarde F, Darii E, Ugarte E, Lescop E, Fonknechten N, Weissenbach J, Woignier T, Gallard JF, Vuilleumier S, Imfeld G, Le Paslier D, Saaidi PL. About Sci Technol. 2019 Jun 4;53(11):6133-6143. doi: 10.1021/acs.est.8b06305. Epub 2019 May 22. PMID: 31082212

YB-1, an abundant core mRNA-binding protein, has the capacity to form an RNA nucleoprotein filament: a structural analysis.

Kretov DA, Clément MJ, Lambert G, Durand D, Lyabin DN, Bollot G, Bauvais C, Samsonova A, Budkina K, Maroun RC, Hamon L, Bouhss A, Lescop E, Toma F, Curmi PA, Maucuer A, Ovchinnikov LP, Pastré D. Nucleic Acids Res. 2019 Apr 8;47(6):3127-3141. doi: 10.1093/nar/gky1303. PMID: 30605522 Free PMC article.

Evidence of Cis/Trans-Isomerization at Pro7/Pro16 in the Lasso Peptide Microcin J25.

Jeanne Dit Fouque K, Hegemann JD, Zirah S, Rebuffat S, Lescop E, Fernandez-Lima F. J Am Soc Mass Spectrom. 2019 Jun;30(6):1038-1045. doi: 10.1007/s13361-019-02134-5. Epub 2019 Mar 4. PMID: 30834511

Structural Characterization of N-WASP Domain V Using MD Simulations with NMR and SAXS Data.

Chan-Yao-Chong M, Deville C, Pinet L, van Heijenoort C, Durand D, Ha-Duong T. Biophys J. 2019 Apr 2;116(7):1216-1227. doi: 10.1016/j.bpj.2019.02.015. Epub 2019 Feb 26. PMID: 30878202 Free PMC article.

Single-Scan Diffusion-Ordered NMR Spectroscopy of SABER-Hyperpolarized Mixtures.

Guduff L, Berthault P, van Heijenoort C, Dumez JN, Huber G. Chemphyschem. 2019 Feb 4;20(3):392-398. doi: 10.1002/cphc.201800983. Epub 2019 Jan 4. PMID: 30521115

Abou Samra, A., A. Robert, C. Gov, L. Favre, L. Eloy, E. Jacquet, J. Bignon, J. Wiels, S. Desrat and F. Roussi (2018). "Dual inhibitors of the pro-survival proteins Bcl-2 and Mcl-1 derived from natural compound meiogynin A." Eur J Med Chem 148: 26-38.

Andre, E., V. Derrien, P. Sebban, N. Assrir, E. Lescop and S. Bernad (2018). "Impact of A90P, F106L and H64V mutations on neuroglobin stability and ligand binding kinetics." J Biol Inorg Chem.

Casiraghi, M., M. Damian, E. Lescop, JL Baneres and LJ Catoire (2018). "Illuminating the Energy Landscape of GPCRs: The Key Contribution of Solution-State NMR Associated with Escherichia coli as an Expression Host." Biochemistry 57(16): 2297-2307.

Cavailles, M., A. Bornet, X. Jaurand, B. Vuichoud, D. Baudouin, M. Baudin, L. Veyre, G. Bodenhausen, JN Dumez, S. Jannin, C. Coperet and C. Thieuleux (2018) . "Tailored Microstructured Hyperpolarizing Matrices for Optimal Magnetic Resonance Imaging." Angew Chem Int Ed Engl 57(25): 7453-7457.

Concilio, MG, C. Jacquemmoz, D. Boyarskaya, G. Masson and JN Dumez (2018). "Ultrafast Maximum-Quantum NMR Spectroscopy for the Analysis of Aromatic Mixtures." Chemphyschem.

Dumez, JN (2018). "Spatial encoding and spatial selection methods in high-resolution NMR spectroscopy." Prog Nucl Magn Reson Spectrosc 109: 101-134.

Dumez, JN (2018). "Hyperpolarized magnetic resonance in chemistry." Magn Reson Chem 56(7): 565.

Gicquel, M., C. Gomez, MC Garcia Alvarez, O. Pamlard, V. Guerineau, E. Jacquet, J. Bignon, A. Voituriez and A. Marinetti (2018). "Inhibition of p53-Murine Double Minute 2 (MDM2) Interactions with 3,3'-Spirocyclopentene Oxindole Derivatives." J Med Chem 61(20): 9386-9392.

Grzela, R., J. Nusbaum, S. Fieulaine, F. Lavecchia, M. Desmadril, N. Nhiri, A. Van Dorsselaer, S. Cianferani, E. Jacquet, T. Meinnel and C. Giglione (2018). "Peptide deformylases from Vibrio parahaemolyticus phage and bacteria display similar deformylase activity and inhibitor binding clefts." Biochim Biophys Acta Proteins Proteom 1866(2): 348-355.

Hamdoun, G., L. Guduff, C. van Heijenoort, C. Bour, V. Gandon and JN Dumez (2018). "Spatially encoded diffusion-ordered NMR spectroscopy of reaction mixtures in organic solvents." Analyst 143(14): 3458-3464.

Huber, G., L. Guduff, P. Berthault, C. van Heijenoort and JN Dumez (2018). "Single-scan diffusion-ordered NMR spectroscopy of SABER-hyperpolarized mixtures." Chemphyschem.

Jacquemmoz, C. and JN Dumez (2018). "Acceleration of 3D DOSY NMR by Spatial Encoding of the Chemical Shift." Chemphyschem.

Malard, F., N. Assrir, M. Alami, S. Messaoudi, E. Lescop and T. Ha-Duong (2018). "Conformational Ensemble and Biological Role of the TCTP Intrinsically Disordered Region: Influence of Calcium and Phosphorylation." J Mol Biol 430(11): 1621-1639.

Molina, CE, E. Jacquet, P. Ponien, C. Munoz-Guijosa, I. Baczko, LS Maier, P. Donzeau-Gouge, D. Dobrev, R. Fischmeister and A. Garnier (2018). "Identification of optimal reference genes for transcriptomic analyzes in normal and diseased human heart." Cardiovascular Res 114(2): 247-258.

Mons, C., T. Botzanowski, A. Nikolaev, P. Hellwig, S. Cianferani, E. Lescop, C. Bouton and MP Golinelli-Cohen (2018). "The H2O2-Resistant Fe-S Redox Switch MitoNEET Acts as a pH Sensor To Repair Stress-Damaged Fe-S Protein." Biochemistry 57(38): 5616-5628.

Morellet, N., X. Li, SA Wieninger, JL Taylor, J. Bischerour, S. Moriau, E. Lescop, B. Bardiaux, N. Mathy, N. Assrir, M. Betermier, M. Nilges, AB Hickman, F. Dyda, NL Craig and E. Guittet (2018). "Sequence-specific DNA binding activity of the cross-brace zinc finger motif of the piggyBac transposase." Nucleic Acids Res 46(5): 2660-2677.

Mouhand, A., A. Belfetmi, M. Catala, V. Larue, L. Zargarian, F. Brachet, RJ Gorelick, C. Van Heijenoort, G. Mirambeau, P. Barraud, O. Mauffret and C. Tisne (2018 ). "Modulation of the HIV nucleocapsid dynamics finely tunes its RNA-binding properties during virion genesis." Nucleic Acids Res 46(18): 9699-9710.

Petitalot, A., E. Dardillac, E. Jacquet, N. Nhiri, J. Guirouilh-Barbat, P. Julien, I. Bouazzaoui, D. Bonte, J. Feunteun, JA Schnell, P. Lafitte, JC Aude, C Nogues, E. Rouleau, R. Lidereau, BS Lopez, S. Zinn-Justin, SM Caputo and UGGB network (2018). "Combining Homologous Recombination and Phosphopeptide-binding Data to Predict the Impact of BRCA1 BRCT Variants on Cancer Risk." Mol Cancer Res.

Plainchont, B., P. Berruyer, JN Dumez, S. Jannin and P. Giraudeau (2018). "Dynamic Nuclear Polarization Opens New Perspectives for NMR Spectroscopy in Analytical Chemistry." Anal Chem 90(6): 3639-3650.

Richard, CA, V. Rincheval, S. Lassoued, J. Fix, C. Cardone, C. Esneau, S. Nekhai, M. Galloux, MA Rameix-Welti, C. Sizun and JF Eleouet (2018). "RSV hijacks cellular protein phosphatase 1 to regulate M2-1 phosphorylation and viral transcription." PLoS Pathog 14(3): e1006920.

Rochat, T., C. Bohn, C. Morvan, TN Le Lam, F. Razvi, A. Pain, C. Toffano-Nioche, P. Ponien, A. Jacq, E. Jacquet, PD Fey, D. Gautheret and P. Bouloc (2018). "The conserved regulatory RNA RsaE down-regulates the arginine degradation pathway in Staphylococcus aureus." Nucleic Acids Res 46(17): 8803-8816.

Romano, M., G. Fusco, HG Choudhury, S. Mehmood, CV Robinson, S. Zirah, JD Hegemann, E. Lescop, MA Marahiel, S. Rebuffat, A. De Simone and K. Beis (2018). "Structural Basis for Natural Product Selection and Export by Bacterial ABC Transporters." ACS Chem Biol 13(6): 1598-1609.

Samson, C., A. Petitalot, F. Celli, I. Herrada, V. Ropars, MH Le Du, N. Nhiri, E. Jacquet, AA Arteni, B. Buendia and S. Zinn-Justin (2018). "Structural analysis of the ternary complex between lamin A/C, BAF and emerin identifies an interface disrupted in autosomal recessive progeroid diseases." Nucleic Acids Res 46(19): 10460-10473.

Tonali, N., J. Kaffy, JL Soulier, ML Gelmi, E. Erba, M. Taverna, C. van Heijenoort, T. Ha-Duong and S. Ongeri (2018). "Structure-activity relationships of beta-hairpin mimics as modulators of amyloid beta-peptide aggregation." Eur J Med Chem 154: 280-293.

Assrir, N., F. Malard and E. Lescop (2017). "Structural Insights into TCTP and Its Interactions with Ligands and Proteins." Results Problem Cell Differ 64: 9-46.

Dumez, JN (2017). "Perspectives on hyperpolarized solution-state magnetic resonance in chemistry." Magn Reson Chem 55(1): 38-46.

Dumez, JN, B. Vuichoud, D. Mammoli, A. Bornet, AC Pinon, G. Stevanato, B. Meier, G. Bodenhausen, S. Jannin and MH Levitt (2017). "Dynamic Nuclear Polarization of Long-Lived Nuclear Spin States in Methyl Groups." J Phys Chem Lett 8(15): 3549-3555.

Grzela, R., J. Nusbaum, S. Fieulaine, F. Lavecchia, M. Desmadril, N. Nhiri, A. Van Dorsselaer, S. Cianferani, E. Jacquet, T. Meinnel and C. Giglione (2018). "Peptide deformylases from Vibrio parahaemolyticus phage and bacteria display similar deformylase activity and inhibitor binding clefts." Biochim Biophys Acta Proteins Proteom 1866(2): 348-355.

Guduff, L., AJ Allami, C. van Heijenoort, JN Dumez and I. Kuprov (2017). "Efficient simulation of ultrafast magnetic resonance experiments." Phys Chem Chem Phys 19(27): 17577-17586.

Guduff, L., I. Kuprov, C. van Heijenoort and JN Dumez (2017). "Spatially encoded 2D and 3D diffusion-ordered NMR spectroscopy." Common Chem (Camb) 53(4): 701-704.

Guduff, L., D. Kurzbach, C. van Heijenoort, D. Abergel and JN Dumez (2017). "Single-Scan(13)C Diffusion-Ordered NMR Spectroscopy of DNP-Hyperpolarized Substrates." Chemistry 23(66): 16722-16727.

Lopez-Castilla, A., B. Vitorge, L. Khoury, N. Morellet, O. Francetic and N. Izadi-Pruneyre (2017). "(1)H, (15)N and (13)C resonance assignments and secondary structure of PulG, the major pseudopilin from Klebsiella oxytoca type 2 secretion system." Biomol NMR Assign 11(2): 155-158.

Mons, C., I. Ferecatu, S. Riquier, E. Lescop, C. Bouton and MP Golinelli-Cohen (2017). "Combined Biochemical, Biophysical, and Cellular Methods to Study Fe-S Cluster Transfer and Cytosolic Aconitase Repair by MitoNEET." Methods Enzymol 595: 83-106.

Munoz-Montesino, C., C. Sizun, M. Moudjou, L. Herzog, F. Reine, A. Igel-Egalon, C. Barbereau, J. Chapuis, D. Ciric, H. Laude, V. Beringue, H Rezaei and M. Dron (2017). "A stretch of residues within the protease-resistant core is not necessary for prion structure and infectivity." Prion 11(1): 25-30.

Pereira, N., C. Cardone, S. Lassoued, M. Galloux, J. Fix, N. Assrir, E. Lescop, F. Bontems, JF Eleouet and C. Sizun (2017). "New Insights into Structural Disorder in Human Respiratory Syncytial Virus Phosphoprotein and Implications for Binding of Protein Partners." J Biol Chem 292(6): 2120-2131.

Rosenberg, JT, N. Shemesh, JA Muniz, JN Dumez, L. Frydman and SC Grant (2017). "Transverse relaxation of selectively excited metabolites in stroke at 21.1 T." Magn Reson Med 77(2): 520-528.

Rouger, L., M. Yon, V. Sarou-Kanian, F. Fayon, JN Dumez and P. Giraudeau (2017). "Ultrafast acquisition of (1)H-(1)H dipolar correlation experiments in spinning elastomers." J Magn Reson 277: 30-35.

Shemesh, N., JT Rosenberg, JN Dumez, SC Grant and L. Frydman (2017). "Distinguishing neuronal from astrocytic subcellular microstructures using in vivo Double Diffusion Encoded 1H MRS at 21.1 T." PLoS One 12(10): e0185232.

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