CRMN Lyon

Platform name
Very High Field Nuclear Magnetic Resonance Center - CRMN
Website
https://www.crmn-lyon.fr/
City
Lyon
Address

CRMN
UMR 5082 CNRS / Claude University
Bernard Lyon 1 / ENS Lyon
5 Rue de la Doua,
69100 Villeurbanne

Scientific Officer
Dr Loic Salmon (This e-mail address is protected against spambots. You need JavaScript enabled to view it.)
Operational manager
Dr Tanguy Le Marchand (This e-mail address is protected against spambots. You need JavaScript enabled to view it.)
Communication correspondent
Dr Tanguy Le Marchand (This e-mail address is protected against spambots. You need JavaScript enabled to view it.)

The Very High Fields NMR Center (CRMN) is a joint research unit of the CNRS, the Claude Bernard University of Lyon 1 and the Ecole Normale Supérieure of Lyon. CRMN teams work on the most fundamental aspects of NMR, at the interface of biology, chemistry and physics, in order to i) develop methodological and instrumental breakthroughs, ii) radically extend the field of application of this spectroscopy, and iii) enable exploration of the structure and dynamics of new ranges of compounds at the atomic scale in key scientific areas with significant societal impact.

The center was designed around the installation of the world's first 1 GHz spectrometer, delivered in the summer of 2009 and progressively fitted with a variety of state-of-the-art accessories (including probes for ultra magic angle rotation -rapids and cryoprobes for the solution). Around this instrument, a platform was built of six other frequency spectrometers 400, 500, 600, 700 and 800 (x2) MHz, offering exceptional research capabilities. Today, the center also hosts a unique hyperpolarized NMR platform with two DNP MAS systems at 400 MHz and 800 MHz, as well as two polarizers for dissolution DNP.

 

Equipment

900 MHs SB Liquid/Solid Bruker Avance III

Description
final shutdown of the spectrometer: beginning of August 2009. solid-state probes: - 1.3 mm H/X double resonance CP-MAS - 2.5 mm H/X double resonance CP-MAS - 3.2 mm 1H/13C/15N triple channel CP-MAS solution probes: -TXI 1H/13C/15N 5mm (1 grad.) -BBO 1H/X

1000MHz SB

Magnetic field
1000 MHz
Description
Bruker Avance NEO Console
Specificities
Equipped for NMR in the liquid state (cryoprobe) and solid state (MAS probes at high speeds)
Measurement probes
Liquid NMR probes:
  • Cryoprobe TXI 1H/13C/15N 3mm (1 grad.)
  • Cryoprobe TXI 1H/13C/15N 5mm (1 grad.)
  • BBO 5mm 1H/X

Solid state NMR probes:

  • 0.7 mm 1H/13C/15N triple resonance CP-MAS
  • 1.3 mm 1H/13C/15N/2D quadruple resonance CP-MAS
  • 1.3 mm H/X dual resonance CP-MAS
  • 2.5 mm H/X (13C -> 31P) double resonance CP-MAS
  • 3.2mm 1H/13C/15N triple resonance CP-MAS

800MHz WB

Magnetic field
800 MHz
Description
Bruker Avance NEO Console
Specificities
Spectrometer equipped for solid-state MAS NMR at high speed and with hyperpolarization by DNP (527 GHz Gyrotron)
Measurement probes

Solid state NMR probes:

  • 1.3 mm triple resonance 1H/13C/15N (+ double resonance mode) CP-MAS
  • 3.2 mm triple resonance 1H/13C/15N E-free
  • 0.7 mm triple resonance 1H/13C/15N (+ double resonance mode) DNP CP-MAS (<100K)
  • 1.3 mm triple resonance 1H/13C/15N (+ double resonance mode) DNP CP-MAS (<100K)
  • 3.2 mm triple resonance 1H/13C/15N (+ double resonance mode) DNP CP-MAS (<100K)
Expertise and services
  • Biological NMR in solution (structure, dynamics, interactions of proteins or nucleic acids)
  • Biological solid-state NMR with ultra-fast sample rotation at the magic angle (membrane proteins, amyloid fibrils, biological assemblies, ...)
  • MAS DNP for the study of surfaces (heterogeneous catalysts, adsorbed compounds, ...)
  • NMR of materials in the solid state with rotation of the sample at the magic angle (catalysts, polymers, ...)
  • Paramagnetic NMR
Other equipment

800 MHz Bruker ADVANCE NEO

• 5 solid NMR probes: 0.7mmHCN, 1.3mmHCN, 1.3mmHCND, 2.5mmBBHX, 3.2mmHCN

• 1 liquid NMR probe: TXI 5mm

• SampleJet autosampler (5 racks of 96 samples and 30 spinners)

• 1 HR-MAS NMR probe

 

700 MHz Bruker ADVANCE III

• 4 solid state NMR probes: 1.3mm HCN, 2.5mm BBHX, 3.2mm HCN, 4mm BBHX

• 2 liquid NMR probes: TXI 5mm, BBO 5mm

• 1 HR-MAS NMR probe

• HR-MAS SamplePro autosampler (50 samples)

 

600 MHz Bruker ADVANCE III

• 2 cryoprobes 5mm: HCND, H/FPCN

• SampleJet autosampler (5 racks of 96 samples and 30 spinners)

 

500 MHz Bruker ADVANCE NEO

• 9 solid-state NMR probes: 0.7mm HXY, 1.3mm HX, 2.5mm BBHX, 2.5mm CRAMPS, 3.2mm HCN, 4mm HXY, 4mm BB HX, 7mm BB HX, Static HX

• Cryocabinet LT-MAS

 

400 MHz Bruker ADVANCE III HD

• Gyrotron 263 GHz

• Cryocabinet LT-MAS

• 2 DNP NMR probes: 1.3mm LTMAS HXY, 3.2mm LTMAS HXY

 

300 MHz / 7.05 Tesla / 198 GHz d-DNP polarizer prototype Bruker ADVANCE III HD

• Cabinet of DNP by dissolution (d-DNP)

• Cryostat 1.2K

• 2 NMR probes 1H/13C, 1H/15N