I am the Director of Research at Miyoshi, a world leader in cosmetic pigment surface treatment. This technology involves applying hydrophobic molecules to pigments to improve their water resistance and feel. Synthetic polymers make up a significant portion of these molecules, raising regulatory questions in light of European restrictions on microplastics.
Olivier Lafon, scientific manager of the very high-field NMR platform at the Lille site of INFRANALYTICS and of the NMR and Inorganic Materials team (RM2I) of the Solid State Catalysis and Chemistry Unit (UCCS), has been appointed to the rank of Knight of the National Order of Merit.
Alicia Vallet, an NMR research engineer at the Institute of Structural Biology (CNRS/CEA/Université Grenoble Alpes), has been awarded the CNRS Crystal Medal for her involvement in the Infranalytics national research infrastructure.
On Friday, January 31, 2025, this facility was inaugurated at the University of Rouen Normandy in the presence of the press and many officials, including the President of the Normandy Region Hervé Morin, the Prefect of Normandy Jean-Benoît Albertini, the Chairman and CEO of the CNRS Antoine Petit, and the Research and Development Director of TotalEnergies Marie-Noëlle Semeria.
Disordered regions are prevalent in proteins responsible for DNA double-strand break repair. NMR and EPR have identified a network of essential interactions.
In this research work, our team explored the possibility of using nuclear magnetic resonance (NMR) in cell, that is to say directly on bacterial cell cultures, to characterize the bacterial periplasm, a front-line cellular compartment. of the action of antibiotics. The objective was to follow the fate of these antibiotics in this compartment, in the presence or absence of the expression by the bacteria of β-lactamase enzymes linked to bacterial resistance. This study shows that in cell NMR constitutes a powerful analytical tool for the study of new molecules targeting the molecular components of the bacterial periplasm.
